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KMID : 1013220180160020102
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Jouranl of the Korean Society of Clinical Toxicology
2018 Volume.16 No. 2 p.102 ~ p.107
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Association between Smoking and Delayed Neuropsychological Sequelae in Acute Carbon Monoxide Poisoning
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Kim Hak-Myeon
Choi Sung-Woo
Nah Sang-Un
Lim Hoon
Kim Gi-Woon
Han Sang-Soo
Lee Young-Hwan
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Abstract
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Purpose: This study examined the association between smoking and delayed neuropsychological sequelae (DNS) in acute carbon monoxide (CO) poisoning.
Methods: Patients admitted to the medical center emergency department from March 2016 to March 2017 because of CO poisoning were examined retrospectively. The patients were divided into two groups: DNS and Non-DNS group. Multiple factors were analyzed to explain DNS, which was assessed by motor disturbances, cognitive impairment, dysphagia, Parkinson-like syndromes, epilepsy, and emotional lability in CO poisoning.
Results: A total of 120 patients were included. The factors related to DNS were smoking (pack-years) (p=0.002) and initial carbon monoxide-hemoglobin level (p=0.015). On the other hand, after multivariate logistic regression analysis, smoking (Odds ratio 1.07; 95% CI, 1.02-1.13; p=0.004) was the only factor associated with DNS.
Conclusion: Smoking is a very reliable factor for predicting the occurrence of DNS. A history of smoking in patients who suffer from CO intoxication is important. If a patient smokes, treatment should be started actively and as soon as possible.
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KEYWORD
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Carbon monoxide poisoning, Delayed neuropsychological sequelae, Smoking
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